Simulation

Significant effort has been devoted to developing real-time, interactive simulations of the cardiovascular system to be used as educational tools, for exploring basic hemodynamic principles in health and disease and for predicting the effects of device- and surgical-based treatments for heart failure. The basic simulation topology is shown below.

Harvi is an App for the iPad that implements such an interactive simulation and also provides a detailed, interactive textbook of cardiovascular physiology. Additional information about Harvi is available at www.pvloops.com.

Model TopographyPV Loop

Related Papers

Mechanical Circulatory Support Devices for Acute Right Ventricular Failure

NK Kapur, ML Esposito, Y Bader, KJ Morine, MS Kiernan, DT Pham and D Burkhoff
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Left Atrial Decompression Pump for Severe Heart Failure With Preserved Ejection Fraction: Theoretical and Clinical Considerations

D Burkhoff, MS Maurer, SM Joseph, JG Rogers, EY Birati, JE Rame, SJ Shah
JACC Heart Fail 2015;3:275-282

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Effects of an interatrial shunt on rest and exercise hemodynamics: results of a computer simulation in heart failure

D Kaye, SJ Shah, BA Borlaug, F Gustafsson, J Komtebedde, S Kubo, C Magnin, MS Maurer, T Feldman and D Burkhoff
J Card Fail 2014;20:212-221

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Computer model of ventricular interaction during left ventricular circulatory support

JC Woodard, DJ Farrar, E Chow, WP Santamore, D Burkhoff, JD Hill
ASAIO Transactions 1989;35:439-441

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Hemodynamic effects of partial ventricular support in chronic heart failure: Results of simulation validated with in vivo data

D Morley, K Litwak, P Ferber, P Spence, R Dowling, B Meyns, B Griffith and D Burkhoff
J.Thorac.Cardiovasc.Surg. 2007;133:21-28

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Surgical ventricular remodeling: a balancing act on systolic and diastolic properties

D Burkhoff and AS Wechsler
J.Thorac.Cardiovasc.Surg. 2006;132:459-463

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The Role of Impaired Myocardial Relaxation in the Production of Elevated Left Ventricular Filling Pressure

I Hay, J Rich, P Ferber, D Burkhoff and MS Maurer
Am.J.Physiol Heart Circ.Physiol 2004;288:H1203-H1206

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An online heart simulator for augmenting first-year medical and dental education

R Kelsey, M Botello, B Millard, J Zimmerman
Proc AMIA Symp 2002:370-374

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Left ventricular volume reduction surgery for heart failure: a physiologic perspective

JH Artrip, M Oz and D Burkhoff
J Thoracic Cardiovasc Surgery 2001;122:775-782

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Heart reduction surgery: an analysis of the impact on cardiac function

ML Dickstein, HM Spotnitz, EA Rose and D Burkhoff
J.Thorac.Cardiovasc.Surg. 1997;113:1032-1040

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Hemodynamic consequences of ventricular interaction as assessed by model analysis

WP Santamore and D Burkhoff
American Journal of Physiology 1991;260 (HCP 29):H146-H157

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Left ventricular interaction with arterial load studied in isolated canine ventricle

K Sunagawa, WL Maughan, D Burkhoff and K Sagawa
American Journal of Physiology 1983;245 (HCP 14):H773-H780

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