Simulation
Significant effort has been devoted to developing real-time, interactive simulations of the cardiovascular system to be used as educational tools, for exploring basic hemodynamic principles in health and disease and for predicting the effects of device- and surgical-based treatments for heart failure. The basic simulation topology is shown below.
Harvi is an App for the iPad that implements such an interactive simulation and also provides a detailed, interactive textbook of cardiovascular physiology. Additional information about Harvi is available at www.pvloops.com.


Related Papers
Rupture of Papillary Muscle and Chordae Tendinae Complicating STEMI: A Call for Action
M Pahuja, S Ranka, K Chauhan, A Patel, O Chehab, A Elmoghrabi, S Mony, T Ando, T Mishra, M Singh, H Abubaker, A Yassin, JJ Glazier, L Afonso, NK Kapur and D Burkhoff
Asaio J 2020
Physiology of Blood Pump Circulation in Heart Failure
A Saxena, N Uriel and D Burkhoff
Mechanical Support for Heart Failure - Current Solutions and New Technologies. 2020. Chapter 5, pages 63-82
Identification of physiologic treatment targets with favourable haemodynamic consequences in heart failure with preserved ejection fraction
DM Kaye, M Byrne, J Mariani, S Nanayakkara and D Burkhoff
ESC Heart Fail 2020;DOI: 10.1002/ehf2.12908
Right Ventricular Afterload Sensitivity Has Been on My Mind
M Pahuja and D Burkhoff
Circ Heart Fail 2019;12:e006345
Hemodynamic Effects of Mechanical Circulatory Support Devices in Ventricular Septal Defect
M Pahuja, B Schrage, D Westermann, MB Basir, AR Garan and D Burkhoff
Circ Heart Fail 2019;12:e005981
Haemodynamic simulation and the effect of early left ventricular unloading in pre-shock acute coronary syndrome
A Schafer, D Burkhoff and J Bauersachs
ESC Heart Fail 2019
Venoarterial Extracorporeal Membrane Oxygenation for Cardiogenic Shock and Cardiac Arrest: Cardinal Considerations for Initiation and Management
P Rao, Z Khalpey, R Smith, D Burkhoff and RD Kociol
Circ Heart Fail 2018;11:e004905
Mechanical Unloading in Heart Failure
N Uriel, G Sayer, S Annamalai, NK Kapur and D Burkhoff
J Am Coll Cardiol 2018;72:569-580
Organ-level validation of a cross-bridge cycling descriptor in a left ventricular finite element model: effects of ventricular loading on myocardial strains
SM Shavik, ST Wall, J Sundnes, D Burkhoff and LC Lee
Physiol Rep 2017;5
Investigating the Role of Interventricular Interdependence in Development of Right Heart Dysfunction During LVAD Support: A Patient-Specific Methods-Based Approach
KL Sack, Y Dabiri, T Franz, SD Solomon, D Burkhoff and JM Guccione
Front Physiol
Extracorporeal Membrane Oxygenation for End-Stage Interstitial Lung Disease With Secondary Pulmonary Hypertension at Rest and Exercise: Insights From Simulation Modeling
S Chicotka, D Burkhoff, ML Dickstein and M Bacchetta
ASAIO J 2017
Mechanical Circulatory Support Devices for Acute Right Ventricular Failure
NK Kapur, ML Esposito, Y Bader, KJ Morine, MS Kiernan, DT Pham and D Burkhoff
Circulation 2017;136:314-326
HVAD Flow Waveform Morphologies: Theoretical Foundation and Implications for Clinical Practice
JD Rich and D Burkhoff
ASAIO J 2017
Avoiding hemodynamic collapse during high-risk percutaneous coronary intervention: Advanced hemodynamics of impella support
S Verma, D Burkhoff, WW O'Neill
Catheter Cardiovasc Interv 2016
Cardiovascular Simulation of Heart Failure Pathophysiology and Therapeutics
D Doshi and D Burkhoff
J Card Fail 2016;22:303-311
Left Atrial Decompression Pump for Severe Heart Failure With Preserved Ejection Fraction: Theoretical and Clinical Considerations
D Burkhoff, MS Maurer, SM Joseph, JG Rogers, EY Birati, JE Rame, SJ Shah
JACC Heart Fail 2015;3:275-282
Effects of an interatrial shunt on rest and exercise hemodynamics: results of a computer simulation in heart failure
D Kaye, SJ Shah, BA Borlaug, F Gustafsson, J Komtebedde, S Kubo, C Magnin, MS Maurer, T Feldman and D Burkhoff
J Card Fail 2014;20:212-221
Computer model of ventricular interaction during left ventricular circulatory support
JC Woodard, DJ Farrar, E Chow, WP Santamore, D Burkhoff, JD Hill
ASAIO Transactions 1989;35:439-441
Right ventricular assist device in end-stage pulmonary arterial hypertension: insights from a computational model of the cardiovascular system
L Punnoose, D Burkhoff, S Rich and EM Horn
Prog Cardiovasc Dis 2012;55:234-243
Hemodynamic effects of partial ventricular support in chronic heart failure: Results of simulation validated with in vivo data
D Morley, K Litwak, P Ferber, P Spence, R Dowling, B Meyns, B Griffith and D Burkhoff
J.Thorac.Cardiovasc.Surg. 2007;133:21-28
Surgical ventricular remodeling: a balancing act on systolic and diastolic properties
D Burkhoff and AS Wechsler
J.Thorac.Cardiovasc.Surg. 2006;132:459-463
The Role of Impaired Myocardial Relaxation in the Production of Elevated Left Ventricular Filling Pressure
I Hay, J Rich, P Ferber, D Burkhoff and MS Maurer
Am.J.Physiol Heart Circ.Physiol 2004;288:H1203-H1206
An online heart simulator for augmenting first-year medical and dental education
R Kelsey, M Botello, B Millard, J Zimmerman
Proc AMIA Symp 2002:370-374
Left ventricular volume reduction surgery for heart failure: a physiologic perspective
JH Artrip, M Oz and D Burkhoff
J Thoracic Cardiovasc Surgery 2001;122:775-782
Heart reduction surgery: an analysis of the impact on cardiac function
ML Dickstein, HM Spotnitz, EA Rose and D Burkhoff
J.Thorac.Cardiovasc.Surg. 1997;113:1032-1040
A theoretical analysis of the effect of pulmonary vasodilation on pulmonary venous pressure: implications for inhaled nitric oxide therapy
ML Dickstein and D Burkhoff
Journal of Heart and Lung Transplant 1996;15:715-721
Explaining load dependence of ventricular contractile properties with a model of excitation-contraction coupling
D Burkhoff
Journal of Molecular and Cellular Cardiology 1994;26:959-978
Why does pulmonary venous pressure rise following the onset of left ventricular dysfunction: a theoretical analysis
D Burkhoff and JV Tyberg
American Journal of Physiology 1993;265 (HCP 34):H1819-H1828
Hemodynamic consequences of ventricular interaction as assessed by model analysis
WP Santamore and D Burkhoff
American Journal of Physiology 1991;260 (HCP 29):H146-H157
Left ventricular interaction with arterial load studied in isolated canine ventricle
K Sunagawa, WL Maughan, D Burkhoff and K Sagawa
American Journal of Physiology 1983;245 (HCP 14):H773-H780