Use of an iPad App to simulate pressure-volume loops and cardiovascular physiology. Adv Physiol Educ 41:415– 424, 2017;doi:10.1152/advan.00204.2016. The purpose of this laboratory exercise is to model the changes in preload, afterload, and contractility on a simulated pressure-volume loop and to correlate those findings with common measurements of clinical cardiovascular physiology. Once students have modeled these changes on a healthy heart, the students are asked to look at a simulated case of cardiogenic shock. Effects on preload, contractility, and afterload are explored, as well as the hemodynamic effects of a number of student-suggested treatment strategies.